Cyclobenzaprine Oral Route Side Effects

However, when abusing Flexeril recreationally, it does become a greater risk to the user. In the first place, Flexeril abuse can end up causing an overdose, the effects of which can be incredibly dangerous. Dangerous fluctuations in body temperature, irregular heartbeat, and even convulsions are all possible from too much cyclobenzaprine recreational use. Flexeril recreational use can also end up leading to the development of physical dependency.

Data sources include IBM Watson Micromedex (updated 3 Sep 2023), Cerner Multum™ (updated 28 Aug 2023), ASHP (updated 10 Aug 2023) and others. The efficacy of FLEXERIL 5 mg was demonstrated in two seven-day, double-blind, controlled clinical trials enrolling 1405 patients. One study compared FLEXERIL 5 mg and 10 mg t.i.d. to placebo; and a second study compared FLEXERIL 5 mg and 2.5 mg t.i.d. to placebo.

And when cyclobenzaprine and alcohol, opioids, or drugs are used in combination, that risk becomes even higher. People will abuse cyclobenzaprine to enhance the effects of alcohol or mind-altering drugs. As a result, the cyclobenzaprine cyclobenzaprine is it flexeril high can actually end up leading to the development of addictions to other drugs as well. Given the potential for abuse of this drug, it’s important to know the proper dosage for this particular muscle relaxer.

Skeletal Muscle Relaxants

However, the truth is cyclobenzaprine belongs to a separate class of chemicals known as a muscle relaxant. Rather than activating opioid receptors like other prescription painkillers, Flexeril instead blocks certain nerve impulses that are sent to the brain. Just because cyclobenzaprine isn’t an opioid though doesn’t mean it hasn’t become a substance of abuse. The DEA found that nearly 25 million prescriptions were given out for cyclobenzaprine, the active ingredient in Flexeril. Flexeril is believed to be much less addictive than other pain killers.

• Based on individual patient response, the dose may be increased to 10 mg three times a day.
• Generic cyclobenzaprine may be under $0.50 for 30 tablets of the 10mg dose through the BuzzRx discount program.
• If a person has liver or kidney problems, the drug may remain in the body for longer.
• Somnus Therapy’s online sleep therapy program can help guide you toward the best approach for treating both acute and chronic insomnia, regardless of the cause.
• We’re committed to sticking by your side throughout the entire process.

Cyclobenzaprine did not demonstrate mutagenic activity in the male mouse at dose levels of up to 20 times the human dose. In the higher dose groups this microscopic change was seen after 26 weeks and even earlier in rats which died prior to 26 weeks; at lower doses, the change was not seen until after 26 weeks. The plasma concentration of cyclobenzaprine is increased in patients with hepatic impairment (see CLINICAL PHARMACOLOGY, Pharmacokinetics, Hepatic Impairment). If you think you may have taken too much cyclobenzaprine and are at risk of an overdose, you may exhibit the following symptoms and need to call 911 immediately. Even if you have insurance, the prices of Robaxin, Fexmid, Amrix, and other muscle relaxants may be cheaper through the BuzzRx discount program.

How to use Flexeril Tablet

Studies have compared cyclobenzaprine, methocarbamol, and other skeletal muscle relaxants and found that they are equally effective in treating acute musculoskeletal conditions. Cyclobenzaprine is one of the most studied skeletal muscle relaxants, with solid evidence and systematic reviews supporting its effectiveness. It is structurally similar to the tricyclic antidepressants and adverse effects similar to those seen with the tricyclic antidepressants are therefore to be expected. FLEXERIL 5 mg should be used for relief of painful muscle spasm along with rest and physical therapy. It should only be used for short periods of time, usually 2-3 weeks FLEXERIL 5 mg is a prescription medicine and should not be taken by patients who have had a recent heart attack or have heart disease. It should not be used by people with an overactive thyroid or who are currently or have recently used MAOIs.

Its actions on the CNS may also cause some of this medicine’s side effects. Abuse of muscle relaxants alone is uncommon; often, it involves other substances. The recommended dose of immediate-release cyclobenzaprine is 5 to 10mg, three times a day, while that for extended-release versions is 15 to 30 mg, once a day. Maximum daily dose for either form is 30 mg over the course of 24 hours. Taking more may result in adverse Flexeril side effects or overdose. A post-marketing surveillance program was carried out in 7607 patients with acute musculoskeletal disorders, and included 297 patients treated with FLEXERIL 10 mg for 30 days or longer.

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Use of FLEXERIL 5 mg with MAOIs can result in serious health complications. Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist.

Cyclobenzaprine (Oral Route)

The potential adverse effects should be communicated clearly to the patient. Because of limited comparable effectiveness data, choice of agent should be based on side-effect profile, patient preference, abuse potential, and possible drug interactions. Whether cyclobenzaprine is superior to other drugs for the management of acute myofascial strain is unclear and it usually adds more side effects with little therapeutic gain (Turturro et al 2003).

It’s not advised to drink alcohol at all while they’re being treated with Flexeril. People that combine Flexeril and alcohol also may not think properly and are more susceptible to making bad choices. Operating a vehicle while intoxicated, walking through a bad part of town, and other risks to physical harm may end up being more likely when abusing Flexeril and alcohol.